Areas C. elegans Neurotransmitters Exocytosis Ultrafast Endocytosis Clocks Axons Transposons Attraction Microscopy
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Spiral worm

jorgensen lab

 
 

The Jorgensen laboratory studies the molecular basis of synaptic transmission, focusing on the mechanisms of synaptic vesicle fusion and synaptic vesicle regeneration.  We use the nematode C. elegans, and cultured rat and mouse hippocampal neurons as model systems.  In addition, we are developing tools for the broader community of geneticists and cell biologists.  For geneticists, we are designing methods to manipulate the genome of the nematode C. elegans – by random mutagenesis using chemical mutagens and transposons, by directed insertion of single copy transgenes, and by directed changes to endogenous genes using CRISPR.  For cell biologists, we are developing methods in super-resolution microscopy to localize and track single proteins, and methods in electron microscopy to capture rapid cellular events. The eventual goal will be to fuse these methods to characterize the molecular topography of the cell in time and space.

We’re Hiring

ES cell reprogramming staff scientist position

•The Jorgensen laboratory is seeking a creative staff scientist to direct development of new methods in generating genetically modified neurons via ES cell reprogramming.

  • This Research Scientist position will require planning and performing tissue culture genome editing and transfection mouse samples to determine the molecular basis of synaptic transmission.

•Cell culture, molecular biology, transfection, and cell sorting (training will be available) will be an essential part of this research.

•Experiments are directed toward publishable results, and authorship can be expected.

Electron microscopy technician

•The Jorgensen laboratory is seeking a detail-oriented and motivated research technician to perform electron microscopy and fluorescence microscopy imaging.

•Training will be provided, and includes all steps for scanning and transmission electron microscopy using novel cutting-edge equipment.

•Half-time or full-time position, and could lead to a career in microscopy.

•Experiments are directed toward publishable results, and authorship can be expected.

To apply for either position, email:
rebecca<dot>mckean<at>utah<dot>edu